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Interferon regulatory factor 1 (IRF-1) is a primary mediator of the cellular antiviral response to retroviral infection. Recent studies have shown that IRF-1 is also required for Toll-like receptor-induced antiviral response in a variety of different cell types. The present study demonstrates that the Toll-like receptor ligands polyinosinic:polycytidylic acid (Poly I:C) and lipopolysaccharide (LPS) induce IRF-1 mRNA and protein in liver, kidney, and thymus of chickens, whereas influenza virus A and Newcastle disease virus, although they both induce interferon, do not induce IRF-1 protein in hepatocytes of chickens. The type I IFN response in chickens requires the activation of IRF-1, inasmuch as in IRF-1 knock-out chickens, influenza virus-induced IFN-alpha mRNA expression was markedly suppressed. Interestingly, IRF-1 knock-down chickens manifested an enhanced IFN-alpha response to influenza virus infection. Hence, we have identified chicken IRF-1 as a novel antiviral regulator and may function as a negative feedback inhibitor of the IFN-alpha response.Q:

Delphi 7 and 64 bit windows

I know this has been asked a lot but I have looked at the other questions and they don’t seem to help me
I’m trying to install a plug in for Delphi 64 bit for a customer who is on 64 bit Windows 7
The installers for 64 bit always fail with „Unable to perform the requested operation“
I did install the 64 bit version of the plug in but because Delphi is 32 bit, I assume the installer thinks that it needs to be 64 bit
So how do I get the 64 bit installer?
Edit 1

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